MovDisordV3, Main, Exploration, bibRecord, 003D91

Brain parenchyma sonography detects preclinical parkinsonism

Identifieur interne : 003D91 ( Main/Exploration ); précédent : 003D90; suivant : 003D92

Brain parenchyma sonography detects preclinical parkinsonism

Auteurs : Uwe Walter [Allemagne] ; Christine Klein [Allemagne] ; Ruediger Hilker [Allemagne] ; Reiner Benecke [Allemagne] ; Peter P. Pramstaller [Italie] ; Dirk Dressler [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2004-12.

RBID : ISTEX:769495CF95B685EB89CE82DC55B762FABE1D9898

Descripteurs français

Pascal (Inist)
- Asymptomatique, Encéphale, Exploration ultrason, Parkinsonisme, Système nerveux pathologie.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Alleles, Asymptomatic, Brain (pathology), Encephalon, Female, Fluorodeoxyglucose F18 (diagnostic use), Humans, Male, Middle Aged, Nervous system diseases, PARK2, Parkinson Disease (genetics), Parkinson Disease (pathology), Parkinson Disease (ultrasonography), Parkinson's disease, Parkinsonism, Point Mutation (genetics), Positron-Emission Tomography, Radiopharmaceuticals (diagnostic use), Sonography, Substantia Nigra (metabolism), Substantia Nigra (ultrasonography), Ubiquitin-Protein Ligases (genetics), brain parenchyma sonography, parkin, substantia nigra, substantia nigra hyperechogenicity.
MESH :
- chemical , diagnostic use : Fluorodeoxyglucose F18, Radiopharmaceuticals.
- genetics : Parkinson Disease, Point Mutation, Ubiquitin-Protein Ligases.
- metabolism : Substantia Nigra.
- pathology : Brain, Parkinson Disease.
- ultrasonography : Parkinson Disease, Substantia Nigra.
- Adult, Aged, Aged, 80 and over, Alleles, Female, Humans, Male, Middle Aged, Positron-Emission Tomography.

Abstract

Substantia nigra (SN) hyperechogenicity on brain parenchyma sonography (BPS) is highly characteristic for idiopathic PD. We studied 7 symptomatic and 7 asymptomatic parkin mutation carriers (PMC) from a large kindred with adult‐onset parkinsonism. BPS revealed larger SN echogenic sizes in PMC with parkin mutations on both alleles (homozygous, compound‐heterozygous), compared to PMC with only one mutated allele (Mann–Whitney U test, P = 0.007). In symptomatic PMC, larger SN echogenic size was correlated with younger age at onset of the disease (Spearman rank correlation, Rho = −0.937, P = 0.002) but not with age, disease duration, or disease severity. BPS demonstrated SN hyperechogenicity, in concordance with abnormal nigrostriatal 18F‐dopa positron emission tomography (PET), in all symptomatic and 3 asymptomatic PMC. In 2 asymptomatic PMC, PET and BPS were normal. However, in another 2 asymptomatic PET‐normal PMC, SN hyperechogenicity could be detected. Data suggest SN hyperechogenicity as an early marker to detect preclinical parkinsonism. © 2004 Movement Disorder Society

Url:

https://api.istex.fr/document/769495CF95B685EB89CE82DC55B762FABE1D9898/fulltext/pdf

DOI: 10.1002/mds.20232

Affiliations:

Allemagne, Italie

Le document en format XML

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<term>Brain (pathology)</term>
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<front><div type="abstract" xml:lang="en">Substantia nigra (SN) hyperechogenicity on brain parenchyma sonography (BPS) is highly characteristic for idiopathic PD. We studied 7 symptomatic and 7 asymptomatic parkin mutation carriers (PMC) from a large kindred with adult‐onset parkinsonism. BPS revealed larger SN echogenic sizes in PMC with parkin mutations on both alleles (homozygous, compound‐heterozygous), compared to PMC with only one mutated allele (Mann–Whitney U test, P = 0.007). In symptomatic PMC, larger SN echogenic size was correlated with younger age at onset of the disease (Spearman rank correlation, Rho = −0.937, P = 0.002) but not with age, disease duration, or disease severity. BPS demonstrated SN hyperechogenicity, in concordance with abnormal nigrostriatal 18F‐dopa positron emission tomography (PET), in all symptomatic and 3 asymptomatic PMC. In 2 asymptomatic PMC, PET and BPS were normal. However, in another 2 asymptomatic PET‐normal PMC, SN hyperechogenicity could be detected. Data suggest SN hyperechogenicity as an early marker to detect preclinical parkinsonism. © 2004 Movement Disorder Society</div>
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Movement Disorders (revue)

Brain parenchyma sonography detects preclinical parkinsonism

Brain parenchyma sonography detects preclinical parkinsonism

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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